Approaching Plato’s Euthyphro with a Calm Distance

Euthyphro Dilemma

The Euthyphro Dilemma

Socrates asks Euthyphro whether the gods value piety because it is good, or if piety is good because the gods value it. If we generalize Socrates’s question, we come to a choice that has exercised tremendous influence in the history of metaphysics. Instead of asking about value, we can talk about any property. Instead of asking about valuing, we can ask about any attitude or activity. Instead o...

A Model of Calm HCI

John N A Brown Interactive Systems (ISYS), Alpen-Adria-Universität (AAU) Universitätsstraße 65-67 9020 Klagenfurt, Carinthia, Austria, and Centre Tecnològic de Recerca per a la Dependència i la Vida Autònoma (CETpD), Universitat Politècnica de Catalunya (UPC) Rambla de l’Exposició, 59-69 08800 Vilanova i la Geltrú, Catalonia, Spain [email protected] Martin Hitz ISYS, AAU Universitätsstraße 65...

A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.

The t(10;11) chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and difficult-to-treat hematopoietic malignancies. CALM-AF10-driven leukemias are characterized by HOXA gene up-regulation and a global reduction in H3K79 methylation. DOT1L, the H3K79 methyltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this re...

Dystrophin: The dead calm of a dogma

Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease leading to severe disability and death of young men. Current interventions are palliative as no treatment improves the long-term outcome. Therefore, new therapeutic modalities with translational potential are urgently needed and abnormalities downstream from the absence of dystrophin are realistic targets. It has been...